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Keep an eye on Carefully (1)pentobarbital will lessen the level or impact of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead into a minimize in fentanyl plasma concentrations, insufficient efficacy or, maybe, growth of a wit